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MEMBERS
Ki Hong Lee, Ph.D.
FORMER LAB MEMBER
AFFILIATION
European Center for Angioscience (ECAS), Mannheim, Germany
DEPARTMENT
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EDUCATION
• 2023.07 – Postdoctoral researcher, European Center for Angioscience (ECAS), Mannheim, Germany
• 2016.11- 2023.07 PhD, German Cancer Research Center (DKFZ), Heidelberg, Germany / Thesis: “Mechanosensitive vascular Wnt signalling is indispensable for liver
homeostasis” / Supervisor: Hellmut G. Augustin
• 2014-2016 M.Sc. System Cancer Science, Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea / Thesis: “Aberrant CD33 expression is associated with aggressive characteristics
of multiple myeloma cells in vitro” / Supervisor: Sun-Young Kong
• 2009-2013 B.Sc. Biology and Physiology, Western University, London, Canada
CONTACT
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PUBLICATIONS
• Lee KH*, Jakab M*, Uvarovskii A, Papageorgiou D, Inverso D, Shi J, Kulkarni SR, Ali SA, Gallage S, Buettner M, Poschet G, Heikenwalder M, Boutros M, Niehrs C, Krijgsveld J, Anders S, Augustin HG. Haemodynamic control of zonated liver function via instructive vascular Wnt signalling. Equal contribution. In revision.
• Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee KH, Geng Y, Rajbhandari P, Hernandez C, Steffani M, Qie J, Savage T, Goyal DM, Ray KC, Neelakantan TV, Yin D, Melms J, Lehrich BM, Yasaka TM, Liu S, Oertel M, Lan T, Guillot A, Peiseler M, Filliol A, Kanzaki H, Fujiwara N, Ravi S, Izar B, Brosch M, Hempe J, Remotti H, Argemi J, Sun Z, Kendall TJ, Hoshida Y, Tacke F, Fallowfield JA, Blockley-Powell SK, Haeusler RA, Steinman JB, Pajvani UB, Monga SP, Bataller R, Masoodi M, Arpaia N, Lee YA, Stockwell BR, Augustin HG, Schwabe RF. Hepatic stellate cells control liver zonation, size and functions via R-spondin 3. Nature. 2025;640(8059):752-761.
• Jakab M*, Lee KH*, Uvarovskii A, Ovchinnikova S, Kulkarni S, Rostalski T, Anders S, Augustin HG. Lung endothelium instructs dormancy of susceptible metastatic tumour cells. Nature Cancer. 2024;5(5):716-730. Equal contribution.
• Jakab M, Rostalski T, Lee KH, Mogler C, Augustin HG. Tie2 Receptor in Tumor-Infiltrating Macrophages Is Dispensable for Tumor Angiogenesis and Tumor Relapse after Chemotherapy. Cancer Research. 2022;82(7):1353-1364.
• Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver. Developmental Cell. 2021;56(11):1677-1693.
• Koch PS*, Lee KH*, Goerdt S, Augustin HG. Angiodiversity and organotypic functions of sinusoidal endothelial cells. Angiogenesis. 2021;24(2):289-230. Equal contribution.
• Lee KJ, Lee KH, Yoon KA, Sohn JY, Lee E, Lee H, Eom HS, Kong SY. Chromothripsis in Treatment Resistance in Multiple Myeloma. Genomics & Informatics. 2017;15(3):87-97.
• Kong SY, Kim KS, Kim J, Kim MK, Lee KH, Lee JY, Oh N, Park JI, Park JH, Heo SH, Shim SH, Lee DR, Kim KP, Park KS. The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo. Oncotarget. 2016;7(40):65137-65146.
AWARDS
• Aegean Conference Trainee Award, 2023
• Robert & Ruth Lumsden Award, University of Western Ontario, 2013
PRESENTATIONS
• Mechanosensitive self-fueling vascular Wnt controls liver function. Presented at: First International Conference of Liver Pathobiology: From Bench to Bedside 2023; Chania, Crete, Greece.
• A mechanosensitive self-fueling vascular Wnt dictates zonated liver function. Presented at: Heidelberg Wnt Symposium 2023; Heidelberg, Germany.
• Mechanosensitive vascular Wnt signaling shapes hepatic vascular resilience and sustains zonated metabolic liver function. Presented at: 22nd International Vascular Biology Meeting 2022; Oakland, CA, USA.
• Vascular Wnt is indispensable for liver homeostasis. Presented at: 11th International Kloster Seeon Meeting “Angiogenesis” 2021; Seeon-Seebruck, Bavaria, Germany.
• Angiocrine Wnt signaling in liver metabolic homeostasis and regeneration. Presented at: Gordon Research Conferences: Wnt Signaling 2019; Mount Snow, West Dover, VT, USA.
• Aberrant expression of CD33 is associated with poor prognosis in patients with multiple myeloma and tumor progression. Presented at: AACR Annual Meeting 2016; New Orleans, LA, USA.
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